40 years of the cell cycle: from foundational discovery to multiscale biology
40 Years of the Cell Cycle: From Foundational Discovery to Multiscale Biology celebrates forty years since the first Jacques Monod Cell Cycle Conference was held in Roscoff. Over four decades, these meetings have played an important role in shaping our understanding of eukaryotic cell-cycle control, providing a forum where fundamental principles were discovered, debated and refined, including work that contributed to the 2001 Nobel Prize awarded to Paul Nurse, Tim Hunt and Lee Hartwell.
This anniversary meeting will celebrate that scientific legacy while looking firmly to the future. Advances in structural biology, quantitative imaging, genomics, proteomics and biophysics are transforming our understanding of cell-cycle regulation, revealing new mechanisms and connections with cell fate, development, ageing and genome stability.
Across 11 scientific sessions, the programme will span scales and systems: from transcriptional and proteomic regulation of proliferation to kinetochores and spindle dynamics; from mitotic entry and exit and chromosome segregation to oocyte divisions and tissue organisation. Speakers include researchers who established foundational principles in the field alongside a new generation bringing emerging approaches and perspectives to cell-cycle biology.
As throughout the Jacques Monod Conference series, discussion and participation will be central to the meeting. Talks selected from submitted abstracts, together with flash talks, poster sessions and extended discussion periods, will give early-career researchers and scientists developing new ideas, approaches and model systems a prominent place in the programme.
Forty years after the first Roscoff Cell Cycle Conference, we will bring the community together to celebrate the discoveries that shaped the field and explore the questions and technologies that will define its future.
Chairperson
Adele Marston
University of Edinburgh Centre for Cell Biology, Max Born Crescent, EH9 3BF Edinburgh, United Kingdom
Phone : +441316507088
E-mail : adele.marston@ed.ac.uk
Vice-chairperson
Julien Dumont
CNRS Institut Jacques Monod, 15 rue Hélène Brion, 75013 Paris, France
Phone : +33157278049
E-mail : julien.dumont@ijm.Fr
(provisional titles)
Vincent Archambault (Université de Montréal, Montreal, Canada)
Phosphoregulation of the nucleolus in Drosophila
David Barford (MRC Laboratory of Molecular Biology, Cambridge, UK)
Insights into mechanisms and regulation of chromosome segregation from kinetochore structures
Francis Barr (University of Oxford, Oxford, UK)
Temporal stress as a universal activator of p53-dependent and independent cell cycle checkpoint responses
Renata Basto (Institut Curie, Paris, France)
GEN1 nuclease safeguards cells after whole genome duplication against mitotic bypass and replication stress sensitivity
Yohanns Bellaïche (Institut Curie, Paris, France)
Control of epithelial tissue cell density
Pascal Bernard (University of Lyon, Lyon, France)
Understanding How Condensin Folds a Chromatinized Genome into Mitotic Chromosomes
Arshad Desai (UC San Diego, La Jolla, USA)
Pathways for spindle assembly
Julien Dumont (Institut Jacques Monod, Paris, France)
Assembling the Oocyte Kinetochore
Matilde Galli (Hubrecht Institute, Utrecht, Netherlands)
Knowing when and how to divide: Mechanisms of cell-cycle remodelling in C. elegans
Monica Gotta (ETH Zürich, Zürich, Switzerland)
UBAP2 and the Hippo Pathway: mechanisms of cell-cycle regulation
Charlotte Kirchhelle (ENS Lyon, Lyon, France)
Divide and polarise - a geometric patterning mechanism during plant morphogenesis
Tomomi Kiyomitsu (Okinawa Institute of Science and Technology, Okinawa, Japan)
Spatiotemporal distribution and function of dynein during cleavage division in large medaka embryos
Lara Kruger (Institut Curie, Paris, France)
From polarity to cell fate: untangling asymmetric cell division in mammals using synthetic biology
Thierry Lorca (CRBM, Montpellier, France)
Tight regulation of the kinase–phosphatase balance in meiotic progression of Xenopus oocytes
Adele Marston (University of Edinburgh, Edinburgh, UK)
Specialised Cell Cycle Regulation in Meiosis
Tobias Meyer (Weill Cornell Medicine, New York, USA)
Cell-cycle entry control by regulation of Cdk, Cdc7, APC/C(Cdh1) and E2F activity and Rb concentration
Gabriel Neurohr (ETH Zürich, Zürich, Switzerland)
Size Matters - Nuclear Meltdown in Senescence
Tomoko Nishiyama (Kyoto University, Kyoto, Japan)
Cohesin Subtype–Specific Regulation of Higher-Order Chromatin Architecture
Paul Nurse (The Francis Crick Institute, London, UK)
New Perspectives on CDKs and Cell Cycle Control
Simone Reber (Max Planck Institute, Berlin, Germany)
The physical chemistry of the cytoplasm as a cell cycle variable
Marie-Emilie Terret (Collège de France, Paris, France)
Mechanics of Oocyte Divisions
Iva Tolić (Ruđer Bošković Institute, Zagreb, Croatia)
Mitotic Origins of Genome Instability and Drug Resistance
Elçin Ünal (University of California, Berkeley, USA)
Nuclear Rejuvenation During Meiosis
Katja Wassmann (Institut Jacques Monod, Paris, France)
Coordinating meiotic cell cycle progression with chromosome segregation in vertebrate oocytes
Sophie Zinn-Justin (CEA, Gif-sur-Yvette, France)
Intrinsically disordered regions in DNA repair: from structural mechanisms to the design of artificial binders
Notification of acceptance or rejection for the submitted paper will be intimated within 15 working days of abstract submission deadline. If your abstract is accepted, you will receive a confirmation e-mail with instructions for joining the meeting.